NON-ENZYMATIC PUFA METABOLITES (Non-enzymatic oxylipins - neo-PUFAs)
ISOPROSTANOIDS
First discovered in 1990 by Morrow and co-workers, these compounds are arachidonic acid (AA) metabolites. Years later, alpha-linolenic acid (ALA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), adrenic acid (AdA) were discovered in vivo.
Our attention in thus turned to the development of efficient and straightforward strategies to access all PUFA metabolites of this cyclopentanic structure.
ISOFURANOIDS
Discovered in 2002, isofurans possess a furanic core. They are described to be formed in high oxygen tension compared to isoprostanoids.
In the same way than for isoprostanoids, we developped several strategies to access these furanic compounds from diverse PUFA.
ISOKETALS
Isoketals were discovered in the late 90's. These compounds are highly reactive species and reacts in vivo with amino acids and formed adducts.
In 2016, we developped a strategy to access these reactive compounds.
All these metabolites are used as biomarkers of oxidative stress. In our group, we use them as standard to perform targeted lipidomic and quantify the formation of these metabolites in several matrices (blood, plasma, urine, sperm, ovocytes, plant (leaves, nuts), algae, oils...
In a second time, thanks to collaborations, these compounds are tested to evaluate their intrincic biological properties (anti-inflammatory, anti-arrhythmic, neurprotective ...).
If you are interested in studying these compounds and you want to collaborate with us, please contact us!
If you want to know which compounds we have in hands, please refer to the PDF files below each metabolite families.
Such by pufa
OMEGA 3
OMEGA 6
ala
glA
sda
dglA
epa
aa
Dpa
aDa
Dha
Dpa
such by family of metabolites
isoprostanoids
isofuranoids
isoketals
For further information on this reasearch area, please check personal website of the reasearcher involved.